Assessment Across the Full Spectrum of
Traumatic Brain Injury, Including Concussion

Question 2

Is  there a functional component
to the brain injury?

(a concussion)

Is there a  structural component to
the brain injury?

(a brain bleed likely visible on
a CT scan or advanced neuroimaging)
  • Helps determine patient disposition, including need for a CT scan

  • Immediate on‐site assessment

  • Efficient, accurate, objective, comprehensive

  • Non‐invasive, EEG‐based technology

  • Reduce unnecessary exposure to radiation

  • Neurocognitive tests and digitized concussion assessments

  • For patients ages 18+

  • For use within 3 days of mild head injury

  • Rx‐Only, not a stand‐alone diagnostic or replacement to CT


Comprehensive Assessment Metrics Configured for Your Needs


Facts about Brain Injury and Concussion

4.8 million brain injury‐related ER visits every year

Taylor CA, Bell JM, Breiding MJ, Xu L. Traumatic Brain Injury–Related Emergency Department Visits,
Hospitalizations, and Deaths — United States, 2007 and 2013 MMWR Surveill Summ 2017;66(No. SS‐9):1–16. DOI:

84% of ER visits for suspected head injury result in a CT Scan

95% of head injuries are mild in nature

91% of CTs performed for mild Traumatic Brain Injury are negative and result in potentially unnecessary radiation exposure.

Korley FK, Kelen GD, Jones CM, Diaz‐Arrastia R. Emergency Department Evaluation of Traumatic Brain Injury
in the United States, 2009–2010. J Head Trauma Rehabil 2016 Nov/Dec;31(6):379‐387.

BrainScope Sensitivity to even the smallest amount of detectable blood (≥1cc)

BrainScope Negative Predictive Value

Hanley D, Prichep LS, Bazarian J, Huff JS, Naunheim R, Garrett J, Jones E, Wright DW, O’Neill J, Badjatia N, Gandhi D, Curley K, Chiacchierini R, O’Neil B, Hack D. Emergency Department Triage of Traumatic Head Injury Using Brain Electrical Activity Biomarkers: A Multisite Prospective Observational Validation Trial. Academic Emergency Medicine. 2017; online ahead of print, DOI:10. 1111/acem.13175

Potential to reduce false positives compared with standard
clinical practice based on BrainScope One’s ability to accurately predict
which patients are likely CT‐positive

Huff JS, Naunheim R, Ghosh Dastidar S, Bazarian J, Michelson EW. Referrals for CT scans in mild TBI patients can be aided by the use of a brain electrical activity biomarker. American Journal of Emergency Medicine. 2017; in press, DOI:10.1016/j.ajem.2017.05.027

FDA Validation Trial:
Structural and Functional Brain Injury

  • Hanley, et al., J Neurotrauma, 2018.
    A brain electrical activity (EEG) based biomarker of functional impairment in traumatic head injury: a multisite validation trial

  • Naunheim, et al., American J Emergency Medicine, 2018.
    Using a brain electrical activity biomarker could aid in the objective identification of mild Traumatic Brain Injury patients

  • Hanley, et. al., Academic Emergency Medicine, 2017.
    Emergency Department triage of traumatic head injury using brain electrical activity: a prospective observational validation trial of clinical efficacy

  • Hack, et al., American J EmergencyMedicine, 2017.
    Demonstration of improved accuracy of prediction of CT+ with EEG compared with LDC alone

  • Huff, et al., American J Emergency Medicine, 2017.
    Referrals for CT scans in mild TBI patients can be by the use of a brain electrical activity biomarker

Technology Description and Explanation

  • Prichep, et al., J Computers Biology Medicine, 2014.
    Classification algorithms for the identification of structural injury in TBI using brain electrical activity

  • Prichep, et al., IEEE Transactions Neural Systems & Rehab Engin., 2012.
    Classification of Traumatic Brain Injury Severity Using Informed Data Reduction in a Series of Binary Classifier Algorithms

Neurocognitive Test Norming for Inclusion of Norms

  •  Vincent, et al., Applied Neuropsychology: Adult, 2016.
    Normative data for neurocognitive assessment on the Ahead 300

Structural Injury Assessment Development

  • Ayaz, et al., American J Emergency Medicine, 2015.
    Comparison of quantitative EEG to Current Clinical Decision Rules for head CT

  • Prichep, et al Neurotrauma, 2015.
    Identification of Hematomas in mTBI injury using an index of quantitative brain electrical activity

  • Michelson, et al., Academic Emergency Medicine, 2014.
    Identification of acute stroke using BrainScope technology

  • Hanley, et al., J Neurotrauma, 2013.
    Use of Brain Electrical Activity for the Identification of Hematomas in Mild TBI

  • O'Neil, et al., Western J Emergency Medicine, 2012.
    Quantitative brain electrical activity in the initial screening of mild traumatic brain injuries

  • Naunheim, et al., American J Emergency Medicine, 2011.
    Automated Electroencephalogram (EEG) Identifies Abnormalities in the ED

  • Naunheim, et al., American J Emergency Medicine, 2010.
    Novel method for detecting brain abnormality in a patient with epidural hematoma: A case report

  • Naunheim, et al., Brain Injury, 2010.
    Use of brain electrical activity to quantify TBI brain dysfunction in the ED

Major Findings in Current Practice

  • Michelson et al., Western J Emergency Medicine, 2018.
    Time spent in the ED for mild TBI patients

  • Curley et al., J of Head Trauma Rehabilitation, 2017. Accepted: Pre-Pub:
    lntracranial pathology (CT+) in ED patients with high GCS and high SAC score

  • O'Neil, et al., Military Medicine, 2014:
    CT positive brain injury in Mild TBI patients presenting with normal SAC

  • Huff & Johar, American J Emergency Medicine, 2014:
    Differences in interpretation of cranial CT in Emergency Department TBI patients by expert neuroradiologists

Please contact us with additional questions at or 1-855-927-2461